Hydrochloric Acid → HCID 11536770, compound

HRID 2358059Notes

Reaction equation

HRID 2358059 reaction equation
[Cl:1][C:2]1[C:7]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]1[CH2:13][CH2:14][N:15]([CH2:18][CH3:19])[CH2:16][CH:17]=1.Cl>[Pt]=O.CO>[Cl:1][C:2]1[C:7]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:12]1[CH2:17][CH2:16][N:15]([CH2:18][CH3:19])[CH2:14][CH2:13]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57448047HCID 57448047, compound

Product 1

HCID 11536770HCID 11536770, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

Preparation according to Example 3: 4-[2-chloro-3-(methylsulfonyl)phenyl]-1-ethyl-1,2,3,6-tetrahydropyridine (0.6 g, 2.0 mmol), methanol (25 ml), platinum oxide (0.15 g). Yield: 0.35 g (58%). The amine was converted to hydrochlorid acid salt and recrystallized from ethanol/diisopropyl ether: M.p. 264-265° C. MS m/z (relative intensity, 70 eV) 301 (M+, 6), 301 (13), 300 (11), 288 (35) 286 (bp).

Workup

  1. customPreparation
  2. customrecrystallized from ethanol/diisopropyl ether

Sources & evidence

ORD record
ord-d5d83224af26416eaf003bd510dade29
Source dataset
uspto-grants-2010_07
Patent number
US07763639B2

Reaction notes

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