Formic Acid → HCID 57448053, compound

HRID 2358078Notes

Reaction equation

HRID 2358078 reaction equation
[CH2:1]([N:3]1[CH2:8][CH:7]=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([S:15]([CH3:17])=[O:16])[C:10]=2[F:18])[CH2:5][CH2:4]1)[CH3:2].C(O)=O>[Pd].C(O)(C)C>[CH2:1]([N:3]1[CH2:8][CH2:7][CH:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([S:15]([CH3:17])=[O:16])[C:10]=2[F:18])[CH2:5][CH2:4]1)[CH3:2]

Participants

5

Reactant 2

HCID 284Formic AcidHCID 58988426HCID 58988426, compound

Product 1

HCID 57448053HCID 57448053, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 3776IsopropanolSolvent

Procedure

Preparation according to Example 2. 1-ethyl-4-[2-fluoro-3-(methylsulfinyl)phenyl]-1,2,3,6-tetrahydropyridine (150 mg, 0.56 mmol), formic acid (0.1 ml, 2.8 mmol), palladium on carbon (0.1 g), isopropanol (20 ml). MS m/z (relative intensity, 70 eV) 269 (M+, 11), 254 (bp), 239 (84), 84 (13), 57 (11).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-5dcbcdb2aa164798b03c601671f2192f
Source dataset
uspto-grants-2010_07
Patent number
US07763639B2

Reaction notes

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