Allyl bromide → HCID 11557980, compound

HRID 2358089Notes

Reaction equation

HRID 2358089 reaction equation
[F:1][C:2]1[C:7]([CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:6][CH:5]=[CH:4][C:3]=1[C:14](=[O:16])[CH3:15].C(=O)([O-])[O-].[K+].[K+].[CH2:23](Br)[CH:24]=[CH2:25]>C(#N)C>[CH2:25]([N:11]1[CH2:10][CH2:9][CH:8]([C:7]2[C:2]([F:1])=[C:3]([C:14](=[O:16])[CH3:15])[CH:4]=[CH:5][CH:6]=2)[CH2:13][CH2:12]1)[CH:24]=[CH2:23]

Participants

5

Reactant 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 57448055HCID 57448055, compound

Product 1

HCID 11557980HCID 11557980, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 1: 1-(2-fluoro-3-piperidin-4-ylphenyl)ethanone (0.01 g), acetonitrile (2 ml), potassium carbonate (0.01 g) and allylbromide (0.01 g). MS m/z (rel. intensity, 70 eV) 261 (M+, 89), 260 (82), 234 (bp), 218 (25), 82 (32).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-e56e8f6cd5b74b6fa3c46fb739f2b5f7
Source dataset
uspto-grants-2010_07
Patent number
US07763639B2

Reaction notes

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