HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Methyl 4-[2-fluoro-3-(methylsulfonyl)-phenyl]piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl 4-[2-fluoro-3-(methylsulfonyl)-phenyl]-3,6-dihydropyridine-1(2H)-carboxylate | HCID 67533257 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | Methyl 4-[2-fluoro-3-(methylsulfonyl)-phenyl]piperidine-1-carboxylate | HCID 67532655 | — |
Reaction Steps
Preparation according to preparation 18: Methyl 4-[2-fluoro-3-(methylsulfonyl)-phenyl]-3,6-dihydropyridine-1(2H)-carboxylate (1.45 g, 4.6 mmol), palladium on carbon (0.2 g) and hydrochloric acid (0.5 ml, conc). Yield: 0.76 g. MS m/z (relative intensity, 70 eV) 315 (M+, 41), 256 (bp), 236 (54), 141 (43) 114 (50).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07763639B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-b24f28556e6841f3b6bbae710cfdb7bb |
| Source note | uspto-grants-2010_07 |