Hydrochloric Acid → Methyl 4-[2-fluoro-3-(methylsulfonyl)-phenyl]piperidine-1-carboxylate

HRID 2358114Notes

Reaction equation

HRID 2358114 reaction equation
[F:1][C:2]1[C:7]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]1[CH2:13][CH2:14][N:15]([C:18]([O:20][CH3:21])=[O:19])[CH2:16][CH:17]=1.Cl>[Pd]>[F:1][C:2]1[C:7]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:12]1[CH2:13][CH2:14][N:15]([C:18]([O:20][CH3:21])=[O:19])[CH2:16][CH2:17]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67533257Methyl 4-[2-fluoro-3-(methylsulfonyl)-phenyl]-3,6-dihydropyridine-1(2H)-carboxylate

Product 1

HCID 67532655Methyl 4-[2-fluoro-3-(methylsulfonyl)-phenyl]piperidine-1-carboxylate

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Preparation according to preparation 18: Methyl 4-[2-fluoro-3-(methylsulfonyl)-phenyl]-3,6-dihydropyridine-1(2H)-carboxylate (1.45 g, 4.6 mmol), palladium on carbon (0.2 g) and hydrochloric acid (0.5 ml, conc). Yield: 0.76 g. MS m/z (relative intensity, 70 eV) 315 (M+, 41), 256 (bp), 236 (54), 141 (43) 114 (50).

Workup

  1. customPreparation
  2. customaccording to preparation 18

Sources & evidence

ORD record
ord-b24f28556e6841f3b6bbae710cfdb7bb
Source dataset
uspto-grants-2010_07
Patent number
US07763639B2

Reaction notes

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