反应详情

To a solution of methyl 4-[2-fluoro-3-(methylsulfonyl)-phenyl]piperidine-1-carboxylate (0.7 g, 2.2 mmol) in ethanol (4 ml), hydrochloric acid (3 M, 10 ml) was added and the mixture was heated at reflux for 24 h. The ethanol was evaporated and the aqueous residue was basified with sodium hydroxide (5 M) and extracted with ethylacetate (3×50 ml). The combined organic phases was washed with brine (50 ml), dried (MgSO4) and evaporated to dryness to give the title compound (0.5 g, 91%). MS m/z (relative intensity, 70 eV) 257 (M+, 6), 237 (95), 208 (83), 173 (bp) 130 (69).

1. temperaturethe mixture was heated
2. temperatureat reflux for 24 h
3. customThe ethanol was evaporated
4. extractionextracted with ethylacetate (3×50 ml)
5. washThe combined organic phases was washed with brine (50 ml)
6. dry with materialdried (MgSO4)
7. customevaporated to dryness