Hydrochloric Acid → HCID 57438788, compound

HRID 2358118Notes

Reaction equation

HRID 2358118 reaction equation
[F:1][C:2]1[C:7]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:6][CH:5]=[CH:4][C:3]=1[C:13]1[CH2:14][CH2:15][NH:16][CH2:17][CH:18]=1.Cl>[Pd].CO>[F:1][C:2]1[C:7]([O:8][C:9]([F:10])([F:11])[F:12])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:13]1[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67532541HCID 67532541, compound

Product 1

HCID 57438788HCID 57438788, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Preparation according to preparation 18: 4-[2-fluoro-3-(trifluoromethoxy)phenyl]-1,2,3,6-tetrahydropyridine (3.33 g, 12.7 mmol), palladium on carbon (0.35 g), hydrochloric acid (0.5 ml), methanol (30 ml). Yield: 2.68 g. MS m/z (relative intensity, 70 eV) 263 (M+, 39), 262 (27), 206 (8), 178 (7) 56 (bp).

Workup

  1. customPreparation
  2. customaccording to preparation 18

Sources & evidence

ORD record
ord-c8dda75ef2124c9eb6f5fd191abad552
Source dataset
uspto-grants-2010_07
Patent number
US07763639B2

Reaction notes

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