Trifluoroacetic acid → HCID 57438805, compound

HRID 2358127Notes

Reaction equation

HRID 2358127 reaction equation
C([O:8][C:9]1[C:10]([F:24])=[C:11]([C:15]2(O)[CH2:20][CH2:19][N:18]([CH2:21][CH3:22])[CH2:17][CH2:16]2)[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1.FC(F)(F)C(O)=O>>[CH2:21]([N:18]1[CH2:17][CH:16]=[C:15]([C:11]2[C:10]([F:24])=[C:9]([OH:8])[CH:14]=[CH:13][CH:12]=2)[CH2:20][CH2:19]1)[CH3:22]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57438804HCID 57438804, compound

Product 1

HCID 57438805HCID 57438805, compound

Procedure

Preparation according to preparation 2: 4-[3-(benzyloxy)-2-fluorophenyl]-1-ethylpiperidin-4-ol (1.9 g, 5.77 mmol), trifluoroacetic acid (5 ml). Yield: 1.1 g. MS m/z (rel. intensity, 70 eV) 221 (M+, bp), 220 (43), 206 (95), 163 (10), 110 (14).

Workup

  1. customPreparation
  2. customaccording to preparation 2

Sources & evidence

ORD record
ord-141667e5c752450595a893df441a0d3a
Source dataset
uspto-grants-2010_07
Patent number
US07763639B2

Reaction notes

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