Hydrochloric Acid → HCID 67532969, compound

HRID 2358133Notes

Reaction equation

HRID 2358133 reaction equation
[CH2:1]([N:3]1[CH2:8][CH:7]=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]3([CH3:20])[O:19][CH2:18][CH2:17][O:16]3)[C:10]=2[F:21])[CH2:5][CH2:4]1)[CH3:2].Cl>[Pd].CO>[CH2:1]([N:3]1[CH2:8][CH2:7][CH:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]3([CH3:20])[O:16][CH2:17][CH2:18][O:19]3)[C:10]=2[F:21])[CH2:5][CH2:4]1)[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67533166HCID 67533166, compound

Product 1

HCID 67532969HCID 67532969, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Preparation according to preparation 18: 1-ethyl-4-[2-fluoro-3-(2-methyl-1,3-dioxolan-2-yl)phenyl]-1,2,3,6-tetrahydropyridine (0.73 g, 2.5 mmol), methanol (20 ml), palladium on carbon (0.32 g) and hydrochloric acid (0.2 ml, conc). Yield: 0.7 g. MS m/z (relative intensity, 70 eV) 293 (M+, 23), 292 (12), 279 (15), 278 (bp) 84 (16).

Workup

  1. customPreparation
  2. customaccording to preparation 18

Sources & evidence

ORD record
ord-5c6b2e8aea5b48aebff57aab525054b6
Source dataset
uspto-grants-2010_07
Patent number
US07763639B2

Reaction notes

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