Hydrochloric Acid → HCID 57438789, compound

HRID 2358137Notes

Reaction equation

HRID 2358137 reaction equation
[CH2:1]([N:3]1[CH2:8][CH:7]=[C:6]([C:9]2[C:10]([F:18])=[C:11]([CH:15]=[CH:16][CH:17]=2)[C:12]([NH2:14])=[O:13])[CH2:5][CH2:4]1)[CH3:2].Cl>[Pd].CO>[CH2:1]([N:3]1[CH2:4][CH2:5][CH:6]([C:9]2[C:10]([F:18])=[C:11]([CH:15]=[CH:16][CH:17]=2)[C:12]([NH2:14])=[O:13])[CH2:7][CH2:8]1)[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57438797HCID 57438797, compound

Product 1

HCID 57438789HCID 57438789, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Preparation according to preparation 18: 3-(1-ethyl-1,2,3,6-tetrahydropyridin-4-yl)-2-fluorobenzamide (0.75 g, 3.0 mmol), methanol (20 ml), palladium on carbon (0.2 g) and hydrochloric acid (0.2 ml, conc.). Yield: 0.57 g. MS m/z (relative intensity, 70 eV) 250 (M+, 48), 249 (26), 236 (34), 235 (bp), 109 (30).

Workup

  1. customPreparation
  2. customaccording to preparation 18

Sources & evidence

ORD record
ord-eb5d3fc738f04a5cacef66113b5f70a4
Source dataset
uspto-grants-2010_07
Patent number
US07763639B2

Reaction notes

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