Methyl chloroformate → Methyl 4-[2-fluoro-3-(methylthio)phenyl]piperazine-1-carboxylate

HRID 2358139Notes

Reaction equation

HRID 2358139 reaction equation
[F:1][C:2]1[C:7]([S:8][CH3:9])=[CH:6][CH:5]=[CH:4][C:3]=1[N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.C(N(CC)CC)C.Cl[C:24]([O:26][CH3:27])=[O:25]>C(Cl)Cl>[F:1][C:2]1[C:7]([S:8][CH3:9])=[CH:6][CH:5]=[CH:4][C:3]=1[N:10]1[CH2:15][CH2:14][N:13]([C:24]([O:26][CH3:27])=[O:25])[CH2:12][CH2:11]1

Participants

5

Reactant 3

HCID 6586Methyl chloroformateHCID 8471TriethylamineHCID 574480731-[2-Fluoro-3-(methylthio)phenyl]piperazine

Product 1

HCID 57448074Methyl 4-[2-fluoro-3-(methylthio)phenyl]piperazine-1-carboxylate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Preparation according to preparation 26: 1-[2-fluoro-3-(methylthio)phenyl]piperazine (1.25 g, 5.53 mmol), triethylamine (1.2 ml, 7.2 mmol), methylen chloride (50 ml), methyl chloroformate (0.49 g, 6.6 mmol). Yield: 1.56 g. MS m/z (rel. intensity, 70 eV) 284 (M+, 99), 196 (bp), 184 (44), 169 (54), 56 (60).

Workup

  1. customPreparation
  2. customaccording to preparation 26

Sources & evidence

ORD record
ord-867b123a2aa4466b9311c7d11765273e
Source dataset
uspto-grants-2010_07
Patent number
US07763639B2

Reaction notes

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