Methanol → HCID 57448076, compound

HRID 2358142Notes

Reaction equation

HRID 2358142 reaction equation
F[C:2]1[C:7]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1.[CH3:19][O-:20].[Na+].CO>CN(C)C=O>[CH3:19][O:20][C:2]1[C:7]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1

Participants

5

Reactant 3

HCID 887MethanolHCID 10942334Sodium MethoxideHCID 57438788HCID 57438788, compound

Product 1

HCID 57448076HCID 57448076, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Preparation according to preparation 34: 4-[2-fluoro-3-(trifluoromethoxy)phenyl]piperidine (1.23 g, 4.7 mmol), N,N-dimethylformamide (20 ml), sodium methoxide in methanol (30%, 2.35 ml, 13.2 mmol). Yield: 1.32 g.

Workup

  1. customPreparation
  2. customaccording to preparation 34

Sources & evidence

ORD record
ord-960aa08988da4eb0aba88f543cd22371
Source dataset
uspto-grants-2010_07
Patent number
US07763639B2

Reaction notes

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