1-Chloroethyl chloroformate → HCID 57448046, compound

HRID 2358148Notes

Reaction equation

HRID 2358148 reaction equation
[CH3:1][S:2]([O:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:12]2[CH2:17][CH2:16][N:15](CC)[CH2:14][CH2:13]2)[C:7]=1[F:20])(=[O:4])=[O:3].ClC(OC(Cl)=O)C>ClCCCl>[CH3:1][S:2]([O:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:12]2[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]2)[C:7]=1[F:20])(=[O:3])=[O:4]

Participants

4

Reactant 2

HCID 5213051-Chloroethyl chloroformateHCID 11493178HCID 11493178, compound

Product 1

HCID 57448046HCID 57448046, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

3-(1-ethylpiperidin-4-yl)-2-fluorophenyl methanesulfonate (0.020 g, 0.033 mmol) was dissolved in dry 1,2-dichloroethane (5 ml) and α-chloroethylchloroformat (0.014 ml, 0.033 mmol) was added. The resulting mixture was refluxed for 1 h, and the solvent was evaporated. MS m/z (rel. intensity, 70 eV) 273 (M+, 2), 195 (11), 194 (bp), 178 (5), 56 (60).

Workup

  1. temperatureThe resulting mixture was refluxed for 1 h
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-947425dcc6974da790456bcb9f458514
Source dataset
uspto-grants-2010_07
Patent number
US07763639B2

Reaction notes

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