5-Benzothiazolamine, 2-methyl- → HCID 15984148, compound

HRID 2358158Notes

Reaction equation

HRID 2358158 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[CH:4]=[C:5]2[CH:11]=[C:10]([C:12]([O:14]CC)=O)[N:9]([CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[CH:19]=3)[C:6]2=[N:7][CH:8]=1.[NH2:27][C:28]1[CH:29]=[CH:30][C:31]2[S:35][C:34]([CH3:36])=[N:33][C:32]=2[CH:37]=1>>[CH3:36][C:34]1[S:35][C:31]2[CH:30]=[CH:29][C:28]([NH:27][C:12]([C:10]3[N:9]([CH2:17][C:18]4[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[CH:19]=4)[C:6]4=[N:7][CH:8]=[C:3]([C:2]([F:1])([F:26])[F:25])[CH:4]=[C:5]4[CH:11]=3)=[O:14])=[CH:37][C:32]=2[N:33]=1

Participants

3

Reactant 2

HCID 362295-Benzothiazolamine, 2-methyl-HCID 66905320Ethyl 1-[(3-fluorophenyl)methyl]-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

Product 1

HCID 15984148HCID 15984148, compoundYield 73.1%

Procedure

The process is performed according to the method described in step 13.5 of Example 13, starting with 0.35 g (0.96 mmol) of ethyl 5-trifluoromethyl-1-[(3-fluorophenyl)methyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxylate (Example 13.4) and 0.17 g (1.06 mmol) of 5-amino-2-methylbenzothiazole. 0.34 g of expected compound is isolated.

Sources & evidence

ORD record
ord-fe5d8f915fdb46b58b65b504753f2f05
Source dataset
uspto-grants-2010_07
Patent number
US07763636B2

Reaction notes

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