1,2-Dimethyl-1H-benzimidazol-5-amine → HCID 15984952, compound

HRID 2358160Notes

Reaction equation

HRID 2358160 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[CH:10]=[C:9]([C:11](OCC)=[O:12])[N:8]([CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=3)[C:5]2=[CH:6][N:7]=1.[NH2:24][C:25]1[CH:35]=[CH:34][C:28]2[N:29]([CH3:33])[C:30]([CH3:32])=[N:31][C:27]=2[CH:26]=1>>[CH3:33][N:29]1[C:28]2[CH:34]=[CH:35][C:25]([NH:24][C:11]([C:9]3[N:8]([CH2:16][C:17]4[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=4)[C:5]4=[CH:6][N:7]=[C:2]([F:1])[CH:3]=[C:4]4[CH:10]=3)=[O:12])=[CH:26][C:27]=2[N:31]=[C:30]1[CH3:32]

Participants

3

Reactant 2

HCID 9653551,2-Dimethyl-1H-benzimidazol-5-amineHCID 67546418HCID 67546418, compound

Product 1

HCID 15984952HCID 15984952, compoundYield 51.2%

Procedure

The process is performed according to the method described in step 2.4 of Example 2, starting with 0.3 g (0.95 mmol) of ethyl 5-fluoro-1-[(3-fluorophenyl)methyl]-1H-pyrrolo[2,3-c]pyridine-2-carboxylate (Example 2.3) and 0.183 g (1.14 mmol) of 5-amino-1,2-dimethylbenzimidazole. 0.21 g of expected compound is isolated.

Sources & evidence

ORD record
ord-862649cc2a3b44f6bac0bf08d0d5a7d9
Source dataset
uspto-grants-2010_07
Patent number
US07763636B2

Reaction notes

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