1,2-Diamino-4,5-difluorobenzene → HCID 22139821, compound

HRID 2358191Notes

Reaction equation

HRID 2358191 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[NH2:10].[Cl:11][C:12]1[C:13]([N:17]=[C:18]=[S:19])=[CH:14][S:15][CH:16]=1>C1COCC1>[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[NH:10][C:18]([NH:17][C:13]1[C:12]([Cl:11])=[CH:16][S:15][CH:14]=1)=[S:19]

Participants

4

Reactant 2

HCID 27367551,2-Diamino-4,5-difluorobenzeneHCID 22139828HCID 22139828, compound

Product 1

HCID 22139821HCID 22139821, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To 1,2-diamino-4,5-difluorobenzene (1.02 g) in THF abs. (15 ml) 4-chloro-3-thienylisothiocyanate (1.25 g, example 52c) dissolved in THF abs. (15 ml) was added. Following the analogous description in example 54a) the desired product was obtained (773 mg).

Workup

  1. addition(15 ml) was added

Sources & evidence

ORD record
ord-757c4ce0f24642b2be45de48ec2e1780
Source dataset
uspto-grants-2010_07
Patent number
US07763643B2

Reaction notes

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