HCID 178515781, compound → 9-Bromo-2-(2-chlorophenyl)-3,6-dihydro-7H-benzo[h]imidazo[4,5-f]isoquinolin-7-one

HRID 2358262Notes

Reaction equation

HRID 2358262 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[Cl:26])[NH:11][C:12]=2[C:13]2[CH:18]=[CH:17][NH:16][C:15](=[O:19])[CH:14]=2)=[CH:4][CH:3]=1>C1COCC1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]2=[C:8]3[N:9]=[C:10]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=4[Cl:26])[NH:11][C:12]3=[C:13]3[C:14]([C:15](=[O:19])[NH:16][CH:17]=[CH:18]3)=[C:4]2[CH:3]=1

Participants

3

Reactant 1

HCID 178515781HCID 178515781, compound

Product 1

HCID 1785186779-Bromo-2-(2-chlorophenyl)-3,6-dihydro-7H-benzo[h]imidazo[4,5-f]isoquinolin-7-one

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Using the general procedure in Example 1 Step E, the intermediate of Example 3 Step B was was irradiated under a high intensity light in THF. 1H NMR (600 MHz, DMSO) δ: 13.87 (s, 1 H), 13.76 (s, 1 H)*, 11.86 (m, 1 H)*,11.77 (m, 1 H), 10.55 (d, J=2.0 Hz, 1 H), 10.49 (d, J=2.0 Hz, 1 H)*, 8.49 (d, J=8.5 Hz, 1 H), 8.41 (d, J=8.5 Hz, 1 H)*, 7.88 (m, 1 H), 7.88 (m, 1 H)*, 7.86 (m, 1 H), 7.81 (m, 1 H)*, 7.70 (m, 1 H), 7.70 (m, 1 H)*, 7.57 (m, 3 H), 7.57 (m, 3H)*, 7.31 (m, 1 H), 7.24 (m, 1 H)* (note: * denotes peaks derived from the minor tautomer): [M+1]+ 424.

Sources & evidence

ORD record
ord-67348a9dc04b494cb001d87bd84c8d08
Source dataset
uspto-grants-2010_07
Patent number
US07763634B2

Reaction notes

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