Hydroxyacetonitrile → HCID 19094668, compound

HRID 2358292Notes

Reaction equation

HRID 2358292 reaction equation
[C:1](#[N:4])[CH2:2]O.[CH2:5]([O:7][CH:8]([O:11][CH2:12][CH3:13])[CH2:9][NH2:10])[CH3:6]>>[CH2:5]([O:7][CH:8]([O:11][CH2:12][CH3:13])[CH2:9][NH:10][CH2:2][C:1]#[N:4])[CH3:6]

Participants

3

Reactant 2

HCID 7857HydroxyacetonitrileHCID 695242,2-Diethoxyethylamine

Product 1

HCID 19094668HCID 19094668, compound

Procedure

A mixture of glycolonitrile (8.33 g, 70% solution in water, 0.1 mol) and aminoacetaldehyde diethyl acetal (14.5 mL, 0.1 mol) was heated to reflux for 3 h. After cooling, the mixture was filtered to remove traces of solid and the filtrate then concentrated in vacuo to give the desired product 4.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 3 h
  3. temperatureAfter cooling
  4. filtrationthe mixture was filtered
  5. customto remove traces of solid
  6. concentrationthe filtrate then concentrated in vacuo

Sources & evidence

ORD record
ord-d07826fe1d8a4a698beb55d360644a52
Source dataset
uspto-grants-2010_07
Patent number
US07763614B2

Reaction notes

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