HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → N-(4-aminomethyl-2-vinylphenyl)methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-butyl N-[4-(methanesulfonylamino)-3-vinylbenzyl]carbamate | HCID 68453842 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(4-aminomethyl-2-vinylphenyl)methanesulfonamide | HCID 57665523 | 177.3% |
Reaction Steps
(4-methanesulfonylamino-3-vinylbenzyl) carbamic acid t-butyl ester (161.6 mg) was put into 100 ml round-bottom flask and dissolved in methylenechloride. To the solution was added trifluoroacetic acid and stirred for one night. After confirming the completion of the reaction with TLC, the reaction solution was concentrated under reduced pressure to yield brown liquid (198.6 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07763657B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-af5db71a6a75490dbfc1e7e25c817962 |
| Source note | uspto-grants-2010_07 |