Trifluoroacetic acid → N-(4-aminomethyl-2-vinylphenyl)methanesulfonamide

HRID 2358371Notes

Reaction equation

HRID 2358371 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])=[C:11]([CH:20]=[CH2:21])[CH:10]=1)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])=[C:11]([CH:20]=[CH2:21])[CH:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68453842tert-butyl N-[4-(methanesulfonylamino)-3-vinylbenzyl]carbamate

Product 1

HCID 57665523N-(4-aminomethyl-2-vinylphenyl)methanesulfonamideYield 177.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(4-methanesulfonylamino-3-vinylbenzyl) carbamic acid t-butyl ester (161.6 mg) was put into 100 ml round-bottom flask and dissolved in methylenechloride. To the solution was added trifluoroacetic acid and stirred for one night. After confirming the completion of the reaction with TLC, the reaction solution was concentrated under reduced pressure to yield brown liquid (198.6 mg).

Workup

  1. customthe completion of the reaction with TLC
  2. concentrationthe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-af5db71a6a75490dbfc1e7e25c817962
Source dataset
uspto-grants-2010_07
Patent number
US07763657B2

Reaction notes

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