HCID 68454771, compound → HCID 68453844, compound

HRID 2358373Notes

Reaction equation

HRID 2358373 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([CH:15]=[CH2:16])[C:12]([NH:17][S:18]([CH3:21])(=[O:20])=[O:19])=[CH:11][C:10]=1[Cl:22])(C)(C)C>C(Cl)Cl.C(O)(C(F)(F)F)=O>[NH2:7][CH2:8][C:9]1[C:10]([Cl:22])=[CH:11][C:12]([NH:17][S:18]([CH3:21])(=[O:20])=[O:19])=[C:13]([CH:15]=[CH2:16])[CH:14]=1

Participants

4

Reactant 1

HCID 68454771HCID 68454771, compound

Product 1

HCID 68453844HCID 68453844, compoundYield 130.74%

Reagents, catalysts & solvents 2

HCID 6422Trifluoroacetic acidCatalystHCID 6344DichloromethaneSolvent

Procedure

To a dried 25 ml round bottom flask was added (2-chloro-4-methanesulfonylamino-5-vinyl-benzyl)-carbamic acid t-butyl ester (103.9 mg, 0.29 mmol) and diluted with methylenechloride. To the solution were added 5-6 drops of CF3COOH and stirred for 12 hours. After confirming the completion of the reaction with TLC, the resulting solution was concentrated under reduced pressure using toluene to yield a brownish syrup (98.1 mg, 130.74%).

Workup

  1. customthe completion of the reaction with TLC
  2. concentrationthe resulting solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-6a0d0b1b0f8848a6905071a69f5dfd83
Source dataset
uspto-grants-2010_07
Patent number
US07763657B2

Reaction notes

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