Trifluoroacetic acid → HCID 86629773, compound

HRID 2358375Notes

Reaction equation

HRID 2358375 reaction equation
C(OC(=O)[NH:7][CH:8]([C:10]1[CH:15]=[CH:14][C:13]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])=[C:12]([CH:21]=[CH2:22])[CH:11]=1)[CH3:9])(C)(C)C.[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27]>C(Cl)Cl>[F:24][C:25]([F:30])([F:29])[C:26]([O-:28])=[O:27].[CH3:20][S:17]([NH:16][C:13]1[CH:14]=[CH:15][C:10]([C@H:8]([NH3+:7])[CH3:9])=[CH:11][C:12]=1[CH:21]=[CH2:22])(=[O:19])=[O:18]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68455950HCID 68455950, compound

Product 1

HCID 86629773HCID 86629773, compoundYield 143.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

[1-(4-methanesulfonylamino-3-vinylphenyl)ethyl]carbamic acid t-butyl ester (158.4 mg, 0.465 mmol, 1 eq.) was put into 100 ml round-bottom flask and dissolved in methylenechloride. To the solution was added trifluoroacetic acid (179.2 μl, 2.326 mmol, 5 eq.) and stirred for one night. After confirming the completion of the reaction with TLC, the reaction solution was concentrated under reduced pressure to yield brown crude liquid (236.7 mg).

Workup

  1. customthe completion of the reaction with TLC
  2. concentrationthe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-99e7c9126dfe437a87fe231e4953fa0e
Source dataset
uspto-grants-2010_07
Patent number
US07763657B2

Reaction notes

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