2-(Trifluoromethyl)aniline → 4-Iodo-2-(trifluoromethyl)aniline

HRID 2358385Notes

Reaction equation

HRID 2358385 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH2:9].[I:12]Cl>C(Cl)Cl>[I:12][C:7]1[CH:6]=[CH:5][C:4]([NH2:9])=[C:3]([C:2]([F:10])([F:11])[F:1])[CH:8]=1

Participants

4

Reactant 2

HCID 69222-(Trifluoromethyl)anilineHCID 24640Iodine chloride

Product 1

HCID 32894324-Iodo-2-(trifluoromethyl)anilineYield 42.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-Trifluoromethylphenylamine (30 mg, 0.21 mmol) and ICl (1.1 eq, 0.24 mmol, 38.97 mg) were added into methylene chloride. The reaction mixture was stirred for 12 hr. The reaction mixture was purified according to step 2 of Example 8 to give a title compound (25.6 mg, 42.48%).

Workup

  1. customThe reaction mixture was purified

Sources & evidence

ORD record
ord-88b17524ca914712b38405136e8f2f3f
Source dataset
uspto-grants-2010_07
Patent number
US07763657B2

Reaction notes

Loading…