HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Trifluoromethyl)aniline → 4-Iodo-2-(trifluoromethyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Trifluoromethyl)aniline | HCID 6922 | — |
| Reactant | Iodine chloride | HCID 24640 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Iodo-2-(trifluoromethyl)aniline | HCID 3289432 | 42.5% |
Reaction Steps
2-Trifluoromethylphenylamine (30 mg, 0.21 mmol) and ICl (1.1 eq, 0.24 mmol, 38.97 mg) were added into methylene chloride. The reaction mixture was stirred for 12 hr. The reaction mixture was purified according to step 2 of Example 8 to give a title compound (25.6 mg, 42.48%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07763657B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-88b17524ca914712b38405136e8f2f3f |
| Source note | uspto-grants-2010_07 |