Triethylamine → (4-Methanesulfonylamino-3-trifluoromethyl-5-vinylbenzyl)carbamic Acid tert-butyl Ester

Participants

Reaction Steps

(4-Amino-3-trifluoromethyl-5-vinylbenzyl)carbamic acid tert-butyl ester (235.6 mg, 0.75 mmol), Methanesulfonyl chloride (5 eq, 3.73 mmol, 288.40 μl), and triethylamine (3 eq, 2.25 mmol, 313.60 μl) were added to methylene chloride. The reaction mixture was stirred for 5 hr. The reaction mixture was purified according to step 5 of Example 8 to give a title product, yellow syrup (89.3 mg, 30.21%).

Provenance & Evidence