反应详情

(4-Amino-3-trifluoromethyl-5-vinylbenzyl)carbamic acid tert-butyl ester (235.6 mg, 0.75 mmol), Methanesulfonyl chloride (5 eq, 3.73 mmol, 288.40 μl), and triethylamine (3 eq, 2.25 mmol, 313.60 μl) were added to methylene chloride. The reaction mixture was stirred for 5 hr. The reaction mixture was purified according to step 5 of Example 8 to give a title product, yellow syrup (89.3 mg, 30.21%).

1. customThe reaction mixture was purified