Triethylamine → HCID 68455313, compound

HRID 2358390Notes

Reaction equation

HRID 2358390 reaction equation
[C:1]([O:5][C:6](=[O:22])[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([CH:15]=[CH2:16])[C:12]([NH2:17])=[C:11]([C:18]([F:21])([F:20])[F:19])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:23][S:24](Cl)(=[O:26])=[O:25].C(N(CC)CC)C>C(Cl)Cl>[C:1]([O:5][C:6](=[O:22])[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([CH:15]=[CH2:16])[C:12]([NH:17][S:24]([CH3:23])(=[O:26])=[O:25])=[C:11]([C:18]([F:20])([F:21])[F:19])[CH:10]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 68456886(4-Amino-3-trifluoromethyl-5-vinylbenzyl)carbamic Acid tert-butyl Ester

Product 1

HCID 68455313HCID 68455313, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(4-Amino-3-trifluoromethyl-5-vinylbenzyl)carbamic acid tert-butyl ester (235.6 mg, 0.75 mmol), Methanesulfonyl chloride (5 eq, 3.73 mmol, 288.40 μl), and triethylamine (3 eq, 2.25 mmol, 313.60 μl) were added to methylene chloride. The reaction mixture was stirred for 5 hr. The reaction mixture was purified according to step 5 of Example 8 to give a title product, yellow syrup (89.3 mg, 30.21%).

Workup

  1. customThe reaction mixture was purified

Sources & evidence

ORD record
ord-b3d82bf3e9284e69ba1174b5f844e68d
Source dataset
uspto-grants-2010_07
Patent number
US07763657B2

Reaction notes

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