Hydrochloric Acid → HCID 68453065, compound

HRID 2358402Notes

Reaction equation

HRID 2358402 reaction equation
C[O:2][C:3](=[O:21])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:8][C:7]=1[NH:16][CH2:17][CH:18]([CH3:20])[CH3:19].[OH-].[Na+].Cl>CO.O>[C:12]([C:9]1[CH:10]=[CH:11][C:6]([CH:5]=[CH:4][C:3]([OH:21])=[O:2])=[C:7]([NH:16][CH2:17][CH:18]([CH3:20])[CH3:19])[CH:8]=1)([CH3:15])([CH3:14])[CH3:13]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68454885HCID 68454885, compound

Product 1

HCID 68453065HCID 68453065, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

3-(4-tert-butyl-2-isobutylaminophenyl)acrylic acid methyl ester (0.08 mmol, 22.8 mg) and NaOH (0.39 mmol, 15.76 mg) were added in methanol and water. The reaction mixture was stirred for 12 hrs. The reaction mixture was acidified with 5% HCl solution. The reaction mixture was concentrated in vacuo to give a solid (22.02 mg, 100%).

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-db44d18018e247e6aae05e8ab0e6667c
Source dataset
uspto-grants-2010_07
Patent number
US07763657B2

Reaction notes

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