Hydrochloric Acid → HCID 68453863, compound

Participants

Reaction Steps

3-[4-tert-Butyl-2-(tetrahydropyran-4-yloxy)phenyl]acrylic acid methyl ester (31.5 mg, 0.099 mmol, 1 eq) and sodium hydroxide (19.8 mg, 0.4955 mmole) were added in methanol and H2O. The reaction mixture was stirred for 12 hrs. The reaction mixture was acidified with 5% HCl. The mixture was concentrated in vacuo to yield 3-[4-tert-Butyl-2-(tetrahydropyran-4-yloxy)-phenyl]acrylic acid (30.1 mg, 100%).

Provenance & Evidence