Hydrochloric Acid → HCID 68453863, compound

HRID 2358407Notes

Reaction equation

HRID 2358407 reaction equation
C[O:2][C:3](=[O:23])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:8][C:7]=1[O:16][CH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1.[OH-].[Na+].Cl>CO.O>[C:12]([C:9]1[CH:10]=[CH:11][C:6]([CH:5]=[CH:4][C:3]([OH:23])=[O:2])=[C:7]([O:16][CH:17]2[CH2:18][CH2:19][O:20][CH2:21][CH2:22]2)[CH:8]=1)([CH3:15])([CH3:13])[CH3:14]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68456409HCID 68456409, compound

Product 1

HCID 68453863HCID 68453863, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

3-[4-tert-Butyl-2-(tetrahydropyran-4-yloxy)phenyl]acrylic acid methyl ester (31.5 mg, 0.099 mmol, 1 eq) and sodium hydroxide (19.8 mg, 0.4955 mmole) were added in methanol and H2O. The reaction mixture was stirred for 12 hrs. The reaction mixture was acidified with 5% HCl. The mixture was concentrated in vacuo to yield 3-[4-tert-Butyl-2-(tetrahydropyran-4-yloxy)-phenyl]acrylic acid (30.1 mg, 100%).

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-4e9c185a5d454b118cc518f85d2b9e04
Source dataset
uspto-grants-2010_07
Patent number
US07763657B2

Reaction notes

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