HCID 68456409, compound → HCID 68454731, compound

HRID 2358408Notes

Reaction equation

HRID 2358408 reaction equation
[CH3:1][O:2][C:3](=[O:23])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:8][C:7]=1[O:16][CH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1>CO.[Pd]>[CH3:1][O:2][C:3](=[O:23])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:8][C:7]=1[O:16][CH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1

Participants

4

Reactant 1

HCID 68456409HCID 68456409, compound

Product 1

HCID 68454731HCID 68454731, compoundYield 97.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

3-[4-tert-Butyl-2-(tetrahydropyran-4-yloxy)phenyl]acrylic acid methyl ester (14.4 mg, 0.045 mmole) and 10 wt. % palladium were added in MeOH. The reaction mixture was stirred overnight under hydrogen atmosphere. The reaction mixture was filtered with celite pad. The filterate was concentrated in vacuo and purified with column chromatography to yield a syrup (14.1 mg, 97.3%).

Workup

  1. filtrationThe reaction mixture was filtered with celite pad
  2. concentrationThe filterate was concentrated in vacuo
  3. custompurified with column chromatography

Sources & evidence

ORD record
ord-7b0106237eae4d50bc8870f68ba8542a
Source dataset
uspto-grants-2010_07
Patent number
US07763657B2

Reaction notes

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