3-(4-tert-Butylphenyl)-2-methylprop-2-enoic acid → 3-(4-tert-Butylphenyl)-2-methylpropanoic acid

HRID 2358410Notes

Reaction equation

HRID 2358410 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]=[C:12]([CH3:16])[C:13]([OH:15])=[O:14])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>[Pd].CO>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([CH3:16])[C:13]([OH:15])=[O:14])=[CH:7][CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 543675503-(4-tert-Butylphenyl)-2-methylprop-2-enoic acid

Product 1

HCID 1066943-(4-tert-Butylphenyl)-2-methylpropanoic acidYield 93.47%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

3-(4-tert-butylphenyl)-2-methylacrylic acid (40.9 mg, 0.19 mmol) and 10 wt. % palladium on activated carbon were added in methanol. The reaction mixture was stirred for 5 hrs under H2 gas. The reaction mixture was filtered with Celite. The filterate was concentrated in vacuo to obtain title compound (39.1 mg, 93.47%).

Workup

  1. filtrationThe reaction mixture was filtered with Celite
  2. concentrationThe filterate was concentrated in vacuo

Sources & evidence

ORD record
ord-8ef4a8f9a6be45418e08ae4eb8b5e5a0
Source dataset
uspto-grants-2010_07
Patent number
US07763657B2

Reaction notes

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