HRID2358438

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(NC(=O)Nc1ccc(C(C)(C)C)cc1)c1ccc(NS(C)(=O)=O)c(C#Cc2ccccc2)c1

HCID68455943

未命名化合物

PRODUCTS

生成物

HCID68455989

未命名化合物

收率 32%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

催化剂HCID131709914

未命名化合物

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

N-(4-{1-[3-(4-tert-Butyl-phenyl)-ureido]-ethyl}-2-phenylethynylphenyl)-methanesulfonamide (50 mg, 0.102 mmol, 1 eq.) and palladium on calcium carbonate, poisoned with lead (Lindlar catalyst) were added in methanol. The reaction mixture stirred 12 hrs under H2 atmosphere. The reaction mixture was filtered with celite pad. The filterate was concentrated in vacuo. The residue was purified with column chromatography (n-Hx:EA=2:1) to yield title compound (16 mg, 32%).

WORKUP

后处理

filtrationThe reaction mixture was filtered with celite pad
concentrationThe filterate was concentrated in vacuo
customThe residue was purified with column chromatography (n-Hx:EA=2:1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ad0c38f166004efeb368192b66db3802
来源数据集: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07763657B2
来源说明: uspto-grants-2010_07

反应 SMILES

[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:35])[NH:13][CH:14]([C:16]2[CH:21]=[CH:20][C:19]([NH:22][S:23]([CH3:26])(=[O:25])=[O:24])=[C:18]([C:27]#[C:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[CH:17]=2)[CH3:15])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>[Pd].CC([O-])=O.CC([O-])=O.[Pb+2].CO.[Pd]>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:35])[NH:13][CH:14]([C:16]2[CH:21]=[CH:20][C:19]([NH:22][S:23]([CH3:26])(=[O:25])=[O:24])=[C:18]([CH:27]=[CH:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[CH:17]=2)[CH3:15])=[CH:7][CH:6]=1)([CH3:2])([CH3:3])[CH3:4]