HCID 68455943, compound → HCID 68455989, compound

Participants

Reaction Steps

N-(4-{1-[3-(4-tert-Butyl-phenyl)-ureido]-ethyl}-2-phenylethynylphenyl)-methanesulfonamide (50 mg, 0.102 mmol, 1 eq.) and palladium on calcium carbonate, poisoned with lead (Lindlar catalyst) were added in methanol. The reaction mixture stirred 12 hrs under H2 atmosphere. The reaction mixture was filtered with celite pad. The filterate was concentrated in vacuo. The residue was purified with column chromatography (n-Hx:EA=2:1) to yield title compound (16 mg, 32%).

Provenance & Evidence