Phosphorus oxide (P4O10) → HCID 13773145, compound

HRID 235864Notes

Reaction equation

HRID 235864 reaction equation
[C:1]([NH:7][CH:8]([C:15]([C:17]1[O:18][CH:19]=[CH:20][CH:21]=1)=[O:16])[CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])(=O)[CH2:2][CH2:3][CH2:4][CH3:5].O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>C(Cl)Cl>[CH2:2]([C:1]1[O:16][C:15]([C:17]2[O:18][CH:19]=[CH:20][CH:21]=2)=[C:8]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:7]=1)[CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 2

HCID 14812Phosphorus oxide (P4O10)HCID 14091130HCID 14091130, compound

Product 1

HCID 13773145HCID 13773145, compoundYield 85.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 5.0 g of ethyl 3-pentanoylamino-3-(2-furylcarbonyl)propionate in 50 ml of methylene chloride is added a mixture of 10 g of phosphorus pentoxide and 10 g of diatomaceous earth. The mixture is refluxed for 6 hours under stirring. After the reaction is completed, the mixture is treated in the same manner as described in Example 2. 4.0 g of ethyl 2-[2-n-butyl-5-(2-furyl)-4-oxazolyl]acetate are thereby obtained as an oil. Yield: 85.1%

Workup

  1. temperatureThe mixture is refluxed for 6 hours
  2. additionthe mixture is treated in the same manner

Sources & evidence

ORD record
ord-14e523bac33c4fe599f7b2e30aae8867
Source dataset
uspto-grants-1987_02
Patent number
US04642313

Reaction notes

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