Phosphorus oxide (P4O10) → HCID 13773145, compound

Participants

Reaction Steps

To a solution of 5.0 g of ethyl 3-pentanoylamino-3-(2-furylcarbonyl)propionate in 50 ml of methylene chloride is added a mixture of 10 g of phosphorus pentoxide and 10 g of diatomaceous earth. The mixture is refluxed for 6 hours under stirring. After the reaction is completed, the mixture is treated in the same manner as described in Example 2. 4.0 g of ethyl 2-[2-n-butyl-5-(2-furyl)-4-oxazolyl]acetate are thereby obtained as an oil. Yield: 85.1%

Provenance & Evidence