反应详情

A suspension of 4-methyl-2-nitrobenzonitrile (5.00 g, 30.8 mmol) and 50% H2SO4 (25 mL) in HOAc (25 mL) was heated to reflux for 22 h. The reaction mixture was poured into ice-water (150 g) under stirring and stirred at 5° C. for 30 minutes. The deposited crystals were collected by filtration, washed with H2O and n-hexane, and dried at 40° C. in vacuum to give the title compound as pale brown crystal (4.85 g, 87%).

1. temperaturewas heated
2. temperatureto reflux for 22 h
3. stirringstirred at 5° C. for 30 minutes
4. filtrationThe deposited crystals were collected by filtration
5. washwashed with H2O and n-hexane
6. customdried at 40° C. in vacuum