Phosphorus oxychloride → HCID 13392282, compound

HRID 235866Notes

Reaction equation

HRID 235866 reaction equation
[C:1]([NH:9][CH:10]([C:17]([C:19]1[O:20][CH:21]=[CH:22][CH:23]=1)=[O:18])[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)=O>C(Cl)(Cl)Cl>[C:2]1([C:1]2[O:18][C:17]([C:19]3[O:20][CH:21]=[CH:22][CH:23]=3)=[C:10]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:9]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 13773132HCID 13773132, compound

Product 1

HCID 13392282HCID 13392282, compoundYield 79.5%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

4.0 g of ethyl 3-benzoylamino-3-(2-furylcarbonyl)propionate, 20 ml of chloroform and 9.7 g of phosphorus oxychloride are treated in the same manner as described in Example 1. 3.0 g of ethyl 2-[2-phenyl-5-(2-furyl)-4-oxazolyl]acetate are thereby obtained. Yield: 78.9%

Sources & evidence

ORD record
ord-7166e9c3ea95409a8a34d973a46830d1
Source dataset
uspto-grants-1987_02
Patent number
US04642313

Reaction notes

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