Phosphorus oxychloride → HCID 13361433, compound

HRID 235867Notes

Reaction equation

HRID 235867 reaction equation
[F:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([NH:8][CH:9]([C:16]([C:18]2[O:19][CH:20]=[CH:21][CH:22]=2)=[O:17])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=O)=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)=O>C(Cl)(Cl)Cl>[F:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]2[O:17][C:16]([C:18]3[O:19][CH:20]=[CH:21][CH:22]=3)=[C:9]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[N:8]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 13773133HCID 13773133, compound

Product 1

HCID 13361433HCID 13361433, compoundYield 79.3%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

20 g of ethyl 3-(4-fluorobenzoylamino)-3-(2-furylcarbonyl)propionate, 100 ml of chloroform and 36.8 g of phosphorus oxychloride are treated in the same manner as described in Example 1. 15 g of ethyl 2-[2-(4-fluorophenyl)-5-(2-furyl)-4-oxazolyl]acetate are thereby obtained. Yield: 78.9%

Sources & evidence

ORD record
ord-033d99d349e14261b704a2ad80ce62a3
Source dataset
uspto-grants-1987_02
Patent number
US04642313

Reaction notes

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