Propylamine → 4-(4-chloro-2-nitrophenoxy)-N-propylbenzamide

HRID 2358686Notes

Reaction equation

HRID 2358686 reaction equation
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:15]=[CH:14][C:10]([C:11](Cl)=[O:12])=[CH:9][CH:8]=2)=[C:4]([N+:18]([O-:20])=[O:19])[CH:3]=1.[CH2:21]([NH2:24])[CH2:22][CH3:23]>>[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:15]=[CH:14][C:10]([C:11]([NH:24][CH2:21][CH2:22][CH3:23])=[O:12])=[CH:9][CH:8]=2)=[C:4]([N+:18]([O-:20])=[O:19])[CH:3]=1

Participants

3

Reactant 2

HCID 7852PropylamineHCID 866154944-(4-Chloro-2-nitrophenoxy)benzoyl chloride

Product 1

HCID 259341484-(4-chloro-2-nitrophenoxy)-N-propylbenzamideYield 100%

Procedure

The product from Example 126c (1.0 g, 3.2 mmol) was reacted with propan-1-amine (568 mg, 9.61 mmol) for 12 h following the procedure from Example 126d giving the title compound (1.02 g, 100%).

Sources & evidence

ORD record
ord-258be9097cdd4ca199cb45c27dbb0648
Source dataset
uspto-grants-2010_07
Patent number
US07763731B2

Reaction notes

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