Phosphorus oxychloride → HCID 13392297, compound

HRID 235870Notes

Reaction equation

HRID 235870 reaction equation
[F:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([NH:8][CH:9]([C:16]([C:18]2[CH:22]=[CH:21][O:20][CH:19]=2)=[O:17])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=O)=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)=O>C(Cl)(Cl)Cl>[F:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]2[O:17][C:16]([C:18]3[CH:22]=[CH:21][O:20][CH:19]=3)=[C:9]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[N:8]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 13773141HCID 13773141, compound

Product 1

HCID 13392297HCID 13392297, compoundYield 66.1%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

8.0 g of ethyl 3-(4-fluorobenzoylamino)-3-(3-furylcarbonyl)propionate, 40 ml of chloroform and 20 g of phosphorus oxychloride are treated in the same manner as described in Example 1. 5.0 g of ethyl 2-[2-(4-fluorophenyl)-5-(3-furyl)-4-oxazolyl]acetate are thereby obtained. Yield: 65.8%

Sources & evidence

ORD record
ord-55eb9dbf2b414736aafa40e58e29dd18
Source dataset
uspto-grants-1987_02
Patent number
US04642313

Reaction notes

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