Phosphorus oxychloride → HCID 13773147, compound

HRID 235873Notes

Reaction equation

HRID 235873 reaction equation
[CH:1]1([C:7]([NH:9][CH:10]([C:17]([C:19]2[O:20][CH:21]=[CH:22][CH:23]=2)=[O:18])[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.P(Cl)(Cl)(Cl)=O>C(Cl)(Cl)Cl>[CH:1]1([C:7]2[O:18][C:17]([C:19]3[O:20][CH:21]=[CH:22][CH:23]=3)=[C:10]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 13773138HCID 13773138, compound

Product 1

HCID 13773147HCID 13773147, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

5.0 g of ethyl 3-cyclohexylcarbonylamino-3-(2-furylcarbonyl)propionate, 30 ml of chloroform and 16.0 g of phosphorus oxychloride are treated in the same manner as described in Example 2. 3.3 g of ethyl 2-[2-cyclohexyl-5-(2-furyl)-4-oxazolyl]acetate are thereby obtained as an oil. Yield: 70.0%

Sources & evidence

ORD record
ord-7baf6826090148a4809030957876b0f6
Source dataset
uspto-grants-1987_02
Patent number
US04642313

Reaction notes

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