Ammonium Chloride → 3-(4-Bromo-benzyloxy)-5-chloro-phenylamine

HRID 2358787Notes

Reaction equation

HRID 2358787 reaction equation
[Br:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][O:7][C:8]2[CH:13]=[C:12]([N+:14]([O-])=O)[CH:11]=[C:10]([Cl:17])[CH:9]=2)=[CH:4][CH:3]=1.[NH4+].[Cl-]>[Fe]>[Br:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][O:7][C:8]2[CH:13]=[C:12]([NH2:14])[CH:11]=[C:10]([Cl:17])[CH:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 25517Ammonium ChlorideHCID 684604931-(4-Bromo-benzyloxy)-3-chloro-5-nitro-benzene

Product 1

HCID 684611983-(4-Bromo-benzyloxy)-5-chloro-phenylamine

Reagents, catalysts & solvents 1

HCID 23925IronCatalyst

Procedure

The product from Example 196a was reduced with Fe and NH4Cl following the procedure from Example 237E to give the title compound.

Sources & evidence

ORD record
ord-92d045e2fc0c4035bd0454e4dd1d14c5
Source dataset
uspto-grants-2010_07
Patent number
US07763731B2

Reaction notes

Loading…