5-Chloro-2-methyl-1,8-naphthyridine → HCID 68460633, compound

HRID 2358799Notes

Reaction equation

HRID 2358799 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([CH3:12])=[N:7]2.[CH3:13][O:14][C:15](=[O:31])[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([O:22][C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][C:24]=2[NH2:30])[CH:17]=1>CCO>[CH3:13][O:14][C:15](=[O:31])[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([O:22][C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][C:24]=2[NH:30][C:2]2[C:3]3[C:8](=[N:7][C:6]([CH3:12])=[CH:5][CH:4]=3)[N:9]=[CH:10][CH:11]=2)[CH:17]=1

Participants

4

Reactant 2

HCID 122663725-Chloro-2-methyl-1,8-naphthyridineHCID 26189305HCID 26189305, compound

Product 1

HCID 68460633HCID 68460633, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

The product from Example 1d (175 mg, 0.979 mmol) and the product from Example 208b (272 mg, 0.979 mmol) were dissolved in 2 mL of abs EtOH and heated to 80° C. for 16 hrs. At this time the reaction mixture was cooled and solvent removed yielding the title compound as a brown foam that was taken forward without purification (410 mg, 93%).

Workup

  1. temperatureAt this time the reaction mixture was cooled
  2. customsolvent removed

Sources & evidence

ORD record
ord-3b75b1169f284326974fb7645d96f273
Source dataset
uspto-grants-2010_07
Patent number
US07763731B2

Reaction notes

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