Ethyl bromoacetate → HCID 13773133, compound

HRID 235895Notes

Reaction equation

HRID 235895 reaction equation
[F:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([NH:8][CH2:9][C:10]([C:12]2[O:13][CH:14]=[CH:15][CH:16]=2)=[O:11])=[O:7])=[CH:4][CH:3]=1.[H-].[Na+].Br[CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24]>>[F:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([NH:8][CH:9]([C:10]([C:12]2[O:13][CH:14]=[CH:15][CH:16]=2)=[O:11])[CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])=[O:7])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 7748Ethyl bromoacetateHCID 24758Sodium hydrideHCID 134707334-Fluoro-N-[2-(furan-2-yl)-2-oxoethyl]benzamide

Product 1

HCID 13773133HCID 13773133, compoundYield 64.9%

Procedure

24.0 g of N-(4-fluorobenzoyl)-(2-furylcarbonyl)methylamine, 4.7 g of 61% sodium hydride and 18.4 g of ethyl bromoacetate are treated in the same manner as described in Preparation 1-(2). 21.0 g of ethyl 3-(4-fluorobenzoylamino)-3-(2-furylcarbonyl)propionate are thereby obtained. Yield: 64.8%

Workup

  1. customas described in Preparation 1-(2)

Sources & evidence

ORD record
ord-ddcd3c002f7c48a2a1979a4f239bef83
Source dataset
uspto-grants-1987_02
Patent number
US04642313

Reaction notes

Loading…