Hydroxylamine → HCID 178513286, compound

HRID 2358980Notes

Reaction equation

HRID 2358980 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([N:7]2[CH:11]=[C:10]([C:12]3[N:17]=[C:16]([C:18](=S)[NH2:19])[CH:15]=[CH:14][CH:13]=3)[CH:9]=[N:8]2)[CH:2]=1.[NH2:21][OH:22]>O1CCOCC1.C1COCC1>[OH:22][NH:21][C:18]([C:16]1[CH:15]=[CH:14][CH:13]=[C:12]([C:10]2[CH:9]=[N:8][N:7]([C:3]3[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=3)[CH:11]=2)[N:17]=1)=[NH:19]

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 58336759HCID 58336759, compound

Product 1

HCID 178513286HCID 178513286, compound

Reagents, catalysts & solvents 1

HCID 22018518Dioxane tetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

With heating, 0.4 g (1.4 mmol) of 6-(1-pyridin-3-yl-1H-pyrazol-4-yl)pyridine-2-carbothioamide were dissolved in 40 ml of dioxane-THF 1:3, 0.4 ml of hydroxylamine (50% strength aqueous solution, corresponds to 6.8 mmol) was added and the mixture was stirred at 60° C. for 1 h and then concentrated by evaporation. The crude product obtained in this manner was not purified any further.

Workup

  1. temperatureWith heating
  2. additionwas added
  3. concentrationconcentrated by evaporation

Sources & evidence

ORD record
ord-c017465f58144527b452a790079744d1
Source dataset
uspto-grants-2014_04
Patent number
US08685964B2

Reaction notes

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