HCID 86657498, compound → HCID 58431974, compound

HRID 2359012Notes

Reaction equation

HRID 2359012 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[C:10]3([CH2:18][C:17]4[C:12](=[CH:13][CH:14]=[C:15]([N+:19]([O-])=O)[CH:16]=4)[CH2:11]3)[O:9][C:8](=[O:22])[NH:7][C:6]=2[N:23]=1>[Pd].CCO>[NH2:19][C:15]1[CH:16]=[C:17]2[C:12](=[CH:13][CH:14]=1)[CH2:11][C:10]1([O:9][C:8](=[O:22])[NH:7][C:6]3[N:23]=[CH:2][CH:3]=[CH:4][C:5]1=3)[CH2:18]2

Participants

4

Reactant 1

HCID 86657498HCID 86657498, compound

Product 1

HCID 58431974HCID 58431974, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 7′-chloro-5-nitro-1,3-dihydrospiro[indene-2,4′-pyrido[2,3-d][1,3]oxazin]-2′(1H)-one from Step A (1.0 g, 3.0 mmol) and 10% palladium on carbon (200 mg) in EtOH (300 mL) is stirred under hydrogen atmosphere for 24 h. The mixture is then filtered through Celite and the filtrate concentrated to give the title compound.

Workup

  1. filtrationThe mixture is then filtered through Celite
  2. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-31b4766d4db9432e9fe93210416de54e
Source dataset
uspto-grants-2014_04
Patent number
US08685965B2

Reaction notes

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