Ethyl bromoacetate → HCID 13773138, compound

HRID 235904Notes

Reaction equation

HRID 235904 reaction equation
[CH:1]1([C:7]([NH:9][CH2:10][C:11]([C:13]2[O:14][CH:15]=[CH:16][CH:17]=2)=[O:12])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[H-].[Na+].Br[CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23]>>[CH:1]1([C:7]([NH:9][CH:10]([C:11]([C:13]2[O:14][CH:15]=[CH:16][CH:17]=2)=[O:12])[CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 7748Ethyl bromoacetateHCID 24758Sodium hydrideHCID 13773128N-[2-(Furan-2-yl)-2-oxoethyl]cyclohexanecarboxamide

Product 1

HCID 13773138HCID 13773138, compoundYield 56.3%

Procedure

6.5 g of N-cyclohexylcarbonyl-(2-furylcarbonyl)methylamine, 1.3 g of 61% sodium hydride and 5.1 g of ethyl bromoacetate are treated in the same manner as described in Preparation 1-(2). 5.0 g ethyl 3-cyclohexylcarbonylamino-3-(2-furylcarbonyl)propionate are thereby obtained. Yield: 56.2%

Workup

  1. customas described in Preparation 1-(2)

Sources & evidence

ORD record
ord-4d813f382b7743fe9af8e038bfc8dd90
Source dataset
uspto-grants-1987_02
Patent number
US04642313

Reaction notes

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