反应详情

温度

80 °C

To a solution of 2-chloro-4-[1-sec-butyl-3-(5-chloro-2-thienyl)-1H-pyrazol-4-yl]pyridine (0.28 mmol) in 2 mL of N,N-dimethylformamide was added molybdenum hexacarbonyl (0.28 mmol), tetrakistriphenylphosphine palladium (0) (0.028 mmol), isopropylamine (0.85 mmol), and 1,8-diazabicyclo(5-4-0)undece-7-ene (0.85 mmol). The mixture was stirred at 80° C. overnight. The solvent was then evaporated and the residue was purified by chromatography on silica gel (hepthane:ethyl acetate 5:1 to 2:1) to afford 30 mg of 4-[1-sec-butyl-3-(5-chloro-2-thienyl)-1H-pyrazol-4-yl]-N-isopropylpyridine-2-carboxamide (26% yield).

1. customThe solvent was then evaporated
2. customthe residue was purified by chromatography on silica gel (hepthane:ethyl acetate 5:1 to 2:1)