反应详情

A mixture of 1-(4-chloro-2-thienyl)ethanone (32.1 mmol) and N,N-dimethylformamide dimethyl acetal (112.2 mmol) was refluxed for 3 h and then allowed to cool to room temperature whereupon crystallization occurred. The reaction mixture was stored in a freezer at −18° C. for 2 h. The supernatant liquid was decanted, the crystals were dried in vacuum to afford 5.3 g (77% yield) of 1-(4-chloro-2-thienyl)-3-(dimethylamino)prop-2-en-1-one which was used in the next step without further purification.

1. temperaturewas refluxed for 3 h
2. customThe supernatant liquid was decanted
3. customthe crystals were dried in vacuum