Hydrazine hydrate (1:1) → HCID 178478298, compound

HRID 2359059Notes

Reaction equation

HRID 2359059 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:7](=O)[CH:8]=[CH:9][N:10](C)C)[S:5][CH:6]=1.O.[NH2:15]N>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:7]2[CH:8]=[CH:9][NH:10][N:15]=2)[S:5][CH:6]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 672602831-(4-Chloro-2-thienyl)-3-(dimethylamino)prop-2-en-1-one

Product 1

HCID 178478298HCID 178478298, compoundYield 99.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1-(4-chloro-2-thienyl)-3-(dimethylamino)prop-2-en-1-one (24.6 mmol) and hydrazine hydrate (49.2 mmol) in 25 mL ethanol was refluxed for 15 h and then allowed to cool to room temperature. The solvent was evaporated under reduced pressure and dried in vacuum to afford 4.5 g (99% yield) 3-(4-chloro-2-thienyl)-1H-pyrazole which was used in the next step without further purification.

Workup

  1. temperaturewas refluxed for 15 h
  2. customThe solvent was evaporated under reduced pressure
  3. customdried in vacuum

Sources & evidence

ORD record
ord-c923b7aeb9654404b556b2ec30f11375
Source dataset
uspto-grants-2014_04
Patent number
US08685974B2

Reaction notes

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